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Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform

Affiliation

  • 1 Institut für Physiologische Chemie, Medizinische Fakulät, Ruhr-Universität, Bochum, Germany.
  • PMID: 8298647
  • DOI: 10.1038/ng1293-381

Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform

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Authors

Affiliation

  • 1 Institut für Physiologische Chemie, Medizinische Fakulät, Ruhr-Universität, Bochum, Germany.
  • PMID: 8298647
  • DOI: 10.1038/ng1293-381

Abstract

Heritable phosphorylase kinase (Phk) deficiency underlies a group of glycogenoses in humans, mice and rats that differ in mode of inheritance and tissue-specificity. It is assumed that this heterogeneity is caused by mutations affecting different subunits and isoforms of Phk. As the first Phk deficiency mutation to be identified, we report a single-nucleotide insertion in the coding sequence of the Phk alpha subunit muscle isoform of the I-strain mouse. This mutation accounts for the virtually complete enzymatic deficiency, the tissue specificity and the X-linked mode of inheritance in this mutant.

Heritable phosphorylase kinase (Phk) deficiency underlies a group of glycogenoses in humans, mice and rats that differ in mode of inheritance and tissue-specificity. It is assumed that this heterogeneity is caused by mutations affecting different subunits and isoforms of Phk. As the first Phk defici …

Purple Hindu Kush might put you to sleep (cannabis review)

Can’t sleep? Purple Hindu Kush might be able to help.

(Alison Gary/Special to The Oregonian)

Can’t sleep? Purple Hindu Kush might be the weed for you.

Kush is a well-known variety that originated in the Kashmir and Jammu regions of Pakistan and Afghanistan. Strains with “Kush” in the name are known for being potent and may be at least partly responsible for giving stoners negative reputation — slow, drowsy, lazy. In fact, Kush’s notoriety is such that Republican Congressman Mark Kirk of Illinois proposed a bill in 2009 to increase criminal penalties for “Kush” strains, while warning of “zombie-like” pot smokers stumbling around the streets of Chicago, high on “kush super-marijuana.”

Purple Hindu Kush is a classic Indica Kush. Consider yourself warned.

Appearance, Scent, and Taste:

Yes, Purple Hindu Kush is purple! Well, dark green with hints of purple . under the right light. It has more brown hairs than crystals and, typical for a Kush, the buds are small and tight but not dense. It is not a particularly exciting looking flower.

Purple Hindu Kush has an earthy, yet sweet aroma with sandalwood, floral and fruity notes. It reminds me of a spring walk through a garden just after rain. Through a fresh waterpipe, it has a strong flavor of fresh cut grass with an earthy aftertaste.

Effects:

I’ve been having trouble writing this review because each time I try some Purple Hindu Kush, I lose my motivation and drift off to sleep. Twice, I’ve awakened in the morning with half of my second bowl left. This is not a good morning varietal; it could definitely derail your day.

I recommend this pure Indica strain for an evening smoke to help wind down from a long day. After a couple of hits (and that’s all I needed), the frenetic commentary in my head slowed down, my eyes got heavy and dry and my muscle spasms began to relax into a strong, fuzzy body high. One drawback — dry mouth. I definitely didn’t turn into a zombie, but I was more drowsy and in less pain than before I smoked.

Cannabis Hangover?

In the comments section of our “Meet The Experts” post, a reader asked for a strain recommendation to help him sleep, but was concerned about getting a “Marijuana hangover.” Cannabis can cause a “hangover” effect, especially when used copiously right before bed. A cannabis hangover generally will make you feel slow and like your head is stuffed with fuzz. Everything may seem a little surreal. It might not be as bad as an alcohol hangover, but is still no fun, especially at work.

Purple Hindu Kush might put you to sleep (cannabis review) Can’t sleep? Purple Hindu Kush might be able to help. (Alison Gary/Special to The Oregonian) Can’t sleep? Purple Hindu Kush